Bulbus Fritillariae Thunbergii (Chinese name zhebeimu) is a famous Chinese medicine, which is derived from the bulbs of the genus Fritillaria thunbergii Miq. (Liliaceae). It has been used as one of the most important antitussive and expectorant drugs for more than 2000 years. Extensive chemical studies have been conducted by many research groups. A number of ingredients were found in Bulbus Fritillariae Thunbergii including isosteroidal alkaloids, steroidal alkaloids and nonalkaloids. Furthermore, pharmacological studies demonstrate that isosteroidal alkaloids are the primary active ingredients responsible for the antitussive activity. Among these alkaloids, verticine and verticinone.